[Ir(P鈭扥P)]-Catalyzed Asymmetric Hydrogenation of Diversely Substituted C鈺怤-Containing Heterocycles

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• 作者：Jos茅 Luis N煤帽ez-Rico ; Anton Vidal-Ferran
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：April 19, 2013
• 年：2013
• 卷：15
• 期：8
• 页码：2066-2069
• 全文大小：275K
• 年卷期：v.15,no.8(April 19, 2013)
• ISSN：1523-7052

文摘

Iridium(I) complexes of enantiomerically pure phosphine-phosphite ligands ([Ir(Cl)(cod)(P鈥擮P)]) efficiently catalyze the enantioselective hydrogenation of diverse C鈺怤-containing heterocyclic compounds (benzoxazines, benzoxazinones, benzothiazinones, and quinoxalinones; 25 examples, up to 99% ee). A substrate-to-catalyst ratio as high as 2000:1 was reached.