In Vitro Antiplasmodial Activity of Extracts of Tristaniopsis Species and Identification of the Active Constituents: Ellagic Acid and 3,4,5-Trimethoxyphenyl-(6'-O-galloyl)-O-
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- 作者：Luisella Verotta ; Mario Dell'Agli ; Andrea Giolito ; Marco Guerrini ; Pierre Cabalion ; and Enrica Bosisio
- 刊名：Journal of Natural Products
- 出版年：2001
- 出版时间：May 2001
- 年：2001
- 卷：64
- 期：5
- 页码：603 - 607
- 全文大小：54K
- 年卷期：v.64,no.5(May 2001)
- ISSN：1520-6025
文摘
Screening of plants from New Caledonia for antiplasmodial activity against Plasmodium falciparumrevealed that methanolic extracts of the leaves and bark of Tristaniopsis calobuxus, T. yateensis, and T.glauca inhibited the growth of chloroquine-sensitive and -resistant clones. Ellagic acid and the newcompound 3,4,5-trimethoxyphenyl-(6'-O-galloyl)-O-
-D-glucopyranoside were identified as the activeconstituents (IC50 0.5 and 3.2 
M, respectively). The growth inhibition of both clones was comparable.The compounds showed negligible or very low cytotoxicity to human skin fibroblasts and Hep G2 cellswhen tested at concentrations ranging from 0.5 to 100 M.
-D-glucopyranoside were identified as the activeconstituents (IC50 0.5 and 3.2 M, respectively). The growth inhibition of both clones was comparable.The compounds showed negligible or very low cytotoxicity to human skin fibroblasts and Hep G2 cellswhen tested at concentrations ranging from 0.5 to 100 M.