Preparation, Stabilization, and Bioefficacy of β-Cyclodextrin Inclusion Compounds of Chloramidophos
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- 作者：Shanshan Zhou ; Lumei Wang ; Anping Zhang ; Kunde Lin ; Weiping Liu
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2008
- 出版时间：April 23, 2008
- 年：2008
- 卷：56
- 期：8
- 页码：2708 - 2713
- 全文大小：240K
- 年卷期：v.56,no.8(April 23, 2008)
- ISSN：1520-5118
文摘
Cyclodextrins are common compounds capable of forming inclusion complexes with a variety of pesticides to improve their solubility, bioavailability, and stability. In this study, chloramidophos (CP) was inclusion-complexed with β-cyclodextrin (β-CD) by a kneading method in an attempt to gain a more stable but equally effecacious formulation compared with CP alone. A 1:1 CP−β-CD complex with an inclusion constant of 203.0 M−1 was determined to exist by UV spectrophotometry. The structural identification, thermal stability, and biological assays of the CP−β-CD complex were then carried out with a product with the maximum guest loading efficiency. The data mearsured by differential scanning calorimetry (DSC), Fourier transform infrared (FT-IR), and X-ray diffraction (XRD), where the endothermic peaks of β-CD, the FT-IR bands, and the XRD peaks were generally changed, deduced the formation of complex. Results of the thermal stability assay showed that the degradation rate of CP in 14-day incubation was slowed by a factor of 3.6 when it was complexed with β-CD. Then, activity and toxicity of CP influenced by the encapsulated process of β-CD were evaluated by an in vitro acetylcholinesterase (AChE) inhibition assay and an acute aquatic toxicity assay, respectively. No significant differences were found in both the two biological assays by a t-test. This indicated that the encapsulation process greatly improved the thermal stability of the pesticide with no adverse effects on bioefficacy compared to that of CP. There is a promising outlook for CP−β-CD to be produced as the active ingredient of various formulation additives of CP for its continued application.