Primer Preactivation of Peptidoglycan Polymerases

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• 作者：Tsung-Shing Andrew Wang ; Tania J. Lupoli ; Yuto Sumida ; Hirokazu Tsukamoto ; Yihui Wu ; Yuriy Rebets ; Daniel E. Kahne ; Suzanne Walker
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：June 8, 2011
• 年：2011
• 卷：133
• 期：22
• 页码：8528-8530
• 全文大小：741K
• 年卷期：v.133,no.22(June 8, 2011)
• ISSN：1520-5126

文摘

Peptidoglycan glycosyltransferases are highly conserved bacterial enzymes that catalyze glycan strand polymerization to build the cell wall. Because the cell wall is essential for bacterial cell survival, these glycosyltransferases are potential antibiotic targets, but a detailed understanding of their mechanisms is lacking. Here we show that a synthetic peptidoglycan fragment that mimics the elongating polymer chain activates peptidoglycan glycosyltransferases by bypassing the rate-limiting initiation step.