Solution-Phase Synthesis of a Highly Substituted Furan Library
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- 作者：Chul-Hee Cho ; Feng Shi ; Dai-Il Jung ; Benjamin Neuenswander ; Gerald H. Lushington ; Richard C. Larock
- 刊名：ACS Combinatorial Science
- 出版年：2012
- 出版时间：July 9, 2012
- 年：2012
- 卷：14
- 期：7
- 页码：403-414
- 全文大小：648K
- 年卷期：v.14,no.7(July 9, 2012)
- ISSN：2156-8944
文摘
A library of furans has been synthesized by iodocyclization and further diversified by palladium-catalyzed coupling processes. The key intermediate 3-iodofurans have been prepared by the electrophilic iodocyclization of 2-iodo-2-alken-1-ones in the presence of various nucleophiles in good to excellent yields under mild reaction conditions. These 3-iodofurans are the key components for library generation through subsequent elaboration by palladium-catalyzed processes, such as Suzuki鈥揗iyaura, Sonagashira, Heck, aminocarbonylation, and carboalkoxylation chemistry to afford a diverse set of 2,3,4,5-tetrasubstituted furans.