Oxidative Damage Mediated by Herbicides on Yeast Cells

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• 作者：Daniela Braconi ; Silvia Possenti ; Marcella Laschi ; Michela Geminiani ; Paola Lusini ; Giulia Bernardini ; Annalisa Santucci
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2008
• 出版时间：May 28, 2008
• 年：2008
• 卷：56
• 期：10
• 页码：3836 - 3845
• 全文大小：4843K
• 年卷期：v.56,no.10(May 28, 2008)
• ISSN：1520-5118

文摘

Agricultural herbicides are among the most commonly used pesticides worldwide, posing serious concerns for both humans, exposed to these chemicals through many routes, and the environment. To clarify the effects of three herbicides as commercial formulations (namely, Pointer, Silglif, and Proper Energy), parameters related to oxidative issues were investigated on an autochthonous wine yeast strain. It was demonstrated that herbicides were able to affect the enzymatic activities of catalase and superoxide dismutase, as well as to induce carbonylation and thiol oxidation as post-translational modifications of proteins. Saccharomyces cerevisiae is an optimal model system to study responses to xenobiotics and oxidative stress. Thus, the results obtained could further the understanding of mechanisms underlying the toxicity of herbicides.