New Alkaloids from Green Vegetable Soybeans and Their Inhibitory Activities on the Proliferation of Concanavalin A-Activated Lymphocytes

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• 作者：Taoyun Wang ; Jianping Zhao ; Xiaoran Li ; Qiongming Xu ; Yanli Liu ; Ikhlas A. Khan ; Shilin Yang
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2016
• 出版时间：March 2, 2016
• 年：2016
• 卷：64
• 期：8
• 页码：1649-1656
• 全文大小：585K
• ISSN：1520-5118

文摘

A comprehensive phytochemical study of the chemical constituents of green vegetable soybeans resulted in the isolation of two new alkaloids, soyalkaloid A, <b>1b>, and isoginsenine, <b>2b>, together with four known ones, ginsenine, <b>3b>, (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, <b>4b>, (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, <b>5b>, and indole-3-carboxylic acid, <b>6b>. The structures of compounds <b>1b>–<b>6b> were elucidated on the basis of spectroscopic and chemical analyses. All of the alkaloids were isolated from soybeans for the first time, and compound <b>1b> was a new indole-type alkaloid with a novel carbocyclic skeleton. Their inhibitory activities on the proliferation of concanalin A-activated lymphocytes were assessed by CCK8 assay.