First Total Synthesis of A2 Isoprostane
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- 作者：Giuseppe Zanoni ; Alessio Porta ; and Giovanni Vidari
- 刊名：Journal of Organic Chemistry
- 出版年：2002
- 出版时间：June 14, 2002
- 年：2002
- 卷：67
- 期：12
- 页码：4346 - 4351
- 全文大小：88K
- 年卷期：v.67,no.12(June 14, 2002)
- ISSN：1520-6904
文摘
A stereoselective Julia-Lythgoe olefination has allowed the first total synthesis of A2 isoprostane(1), a recently discovered member of the growing isoprostane family. This elusive compound opensup numerous new avenues for the molecular biology of cyclopentenone prostaglandins, which areendowed of intriguing biological effects such as antitumor, antiinflammatory, and antiviral activities.