Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439

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• 作者：Shing-Hing Lau ; Alicia Galv谩n ; Rohan R. Merchant ; Claudio Battilocchio ; Jos茅 A. Souto ; Malcolm B. Berry ; Steven V. Ley
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：July 2, 2015
• 年：2015
• 卷：17
• 期：13
• 页码：3218-3221
• 全文大小：304K
• ISSN：1523-7052

文摘

An efficient preparation of the antimalarial drug candidate OZ439, which was obtained by integrating a machine-assisted approach with batch processes, is reported. This approach allows a rapid and cost-effective production of the key intermediates that were readily elaborated into the target molecule.