Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus

详细信息    查看全文

• 作者：Peng Fu ; John B. MacMillan
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：June 19, 2015
• 年：2015
• 卷：17
• 期：12
• 页码：3046-3049
• 全文大小：304K
• ISSN：1523-7052

文摘

Spithioneines A and B (<b>1b> and <b>2b>), two new bohemamine-type pyrrolizidine alkaloids possessing an unusual ergothioneine moiety, were isolated from a marine-derived Streptomyces spinoverrucosus. Their structures were elucidated by spectroscopic analysis, CD spectra, and chemical degradation and synthesis. Compounds <b>1b> and <b>2b> are rare natural products that incorporate the amino acid ergothioneine.