High-Throughput Nuclear Magnetic Resonance Analysis Using a Multiple Coil Flow Probe

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• 作者：Megan A. Macnaughtan ; Ting Hou ; Jun Xu ; and Daniel Raftery
• 刊名：Analytical Chemistry
• 出版年：2003
• 出版时间：October 1, 2003
• 年：2003
• 卷：75
• 期：19
• 页码：5116 - 5123
• 全文大小：221K
• 年卷期：v.75,no.19(October 1, 2003)
• ISSN：1520-6882

文摘

An automated method for high-throughput nuclear magnetic resonance (NMR) spectroscopy has been developedusing a four-coil Multiplex NMR probe. The probe isconstructed with solenoidal microcoils optimized fordetection of small volume, mass-limited samples and aflow-through design. Four samples can be simultaneouslyinjected into the Multiplex probe with a robotics liquidhandler and then analyzed in rapid succession using aselective excitation experiment. Due to the simultaneousinjection of four samples and the reduced analysis timewith rapid selective excitation, the analysis rate achievedthus far is as low as 1 sample/34 s for 1D ¹H NMR.