Cytoprotective Effect of Hydroxytyrosyl Alkyl Ether Derivatives after Oral Administration to Rats in a Model of Glucose鈥揙xygen Deprivation in Brain Slices
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- 作者：Javier Mu帽oz-Mar铆n ; Jos茅 Pedro De La Cruz ; Ana Guerrero ; Inmaculada L贸pez-Leiva ; Juan Antonio L贸pez-Villodres ; Jos茅 Julio Reyes ; Jos茅 Luis Espartero ; Andr茅s Madrona ; Mar铆a Teresa Labajos ; Jos茅 Antonio Gonz谩lez-Correa
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2012
- 出版时间：August 8, 2012
- 年：2012
- 卷：60
- 期：31
- 页码：7659-7664
- 全文大小：238K
- 年卷期：v.60,no.31(August 8, 2012)
- ISSN：1520-5118
文摘
This study was designed to determine whether the oral administration of hydroxytyrosol (HT) alkyl ether derivatives has a neuroprotective effect in rats. The animals were treated for 7 days with HT or ethyl, butyl, hexyl, octyl, and dodecyl HT ether. A method of in vitro hypoxia鈥搑eoxygenation in brain slices was used. Hexyl, octyl, and dodecyl HT derivatives reduced brain cell death (LDH efflux). Lipid peroxidation and nitrite concentrations were inhibited most by hexyl, octyl, and dodecyl derivatives. Concentrations of 3-nitrotyrosine were reduced by HT butyl, hexyl, octyl, and dodecyl ether derivatives. Interleukin-1尾 was significantly reduced in brain slices from rats treated with all HT ether derivatives. LDH efflux showed a linear correlation with brain concentrations of lipid peroxides, nitrites plus nitrates, and interleukin 1尾. The reduction in oxidative and nitrosative stress and decreased production of pro-inflammatory interleukins may be the basis for the observed neuroprotective effects.