Characterization of the Congeners in the Lantibiotic NAI-107 Complex

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• 作者：Sonia I. Maffioli ; Marianna Iorio ; Margherita Sosio ; Paolo Monciardini ; Eleonora Gaspari ; Stefano Donadio
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：January 24, 2014
• 年：2014
• 卷：77
• 期：1
• 页码：79-84
• 全文大小：360K
• ISSN：1520-6025

文摘

NAI-107, a lantibiotic produced by Microbispora sp. 107891, shows potent activity against multi-drug-resistant bacterial pathogens. It is produced as a complex of related molecules, which is unusual for ribosomally synthesized peptides. Here we describe the identification, characterization, and antibacterial activity of the congeners produced by Microbispora sp. 107891 and by the related Microbispora corallina NRRL 30420. These molecules differ by the presence of two, one, or zero hydroxyl groups at Pro-14, by the presence of a chlorine at Trp-4, and/or by the presence of a sulfoxide on the thioether of the first lanthionine.