鈥淐lick鈥?Chemistry-Mediated Phenylene-Cored Carborane Dendrimers

详细信息    查看全文

• 作者：Barada Prasanna Dash ; Rashmirekha Satapathy ; Barrie P. Bode ; Cory T. Reidl ; James W. Sawicki ; Allen J. Mason ; John A. Maguire ; Narayan S. Hosmane
• 刊名：Organometallics
• 出版年：2012
• 出版时间：April 9, 2012
• 年：2012
• 卷：31
• 期：7
• 页码：2931-2935
• 全文大小：246K
• 年卷期：v.31,no.7(April 9, 2012)
• ISSN：1520-6041

文摘

Phenylene-cored small dendrimers containing three to nine peripheral o-carborane clusters were synthesized via Cu(I)-catalyzed Huisgen-type azide alkyne cycloaddition reactions. The resulting dendrimers have been characterized by IR and NMR spectroscopy and MALDI-TOF mass spectral analysis. The biological evaluation of branched dendrimer 16 containing nine carborane cages has been carried out using human liver cancer cells (SK-Hep1). Dendrimer 16 was accumulated in the SK-Hep1 cancer cells in a concentration-dependent manner. The highest boron accumulation up to 2540 ng of boron/5 脳 10⁵ cells was observed at a 50 渭M concentration of 16 over a period of 20 h. The high accumulation of 16 into the tumor cell lines indicates that such dendritic boron drug delivery platforms could be possible for application in boron neutron capture therapy in cancer treatment.