Temperature-Triggered Fusion of Vesicles Composed of Right-Handed and Left-Handed Amphiphilic Helical Peptides

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• 作者：Motoki Ueda ; Akira Makino ; Tomoya Imai ; Junji Sugiyama ; Shunsaku Kimura
• 刊名：Langmuir
• 出版年：2011
• 出版时间：April 19, 2011
• 年：2011
• 卷：27
• 期：8
• 页码：4300-4304
• 全文大小：894K
• 年卷期：v.27,no.8(April 19, 2011)
• ISSN：1520-5827

文摘

Vesicles prepared from a mixture of (Sar)₂₅-b-(l-Leu-Aib)₆ (SLL) and (Sar)₂₅-b-(d-Leu-Aib)₆ (SDL) fused with themselves upon heating to 90 掳C. The vesicles also fused with (Sar)₂₈-b-(l-Leu-Aib)₈ vesicles upon heating to 90 掳C. The temperature-triggered fusion was due to the phase transition of the mixed membrane of SLL and SDL at 90 掳C and should be driven by the bending energy stored in the stereocomplex membrane upon taking a vesicular structure.