Pteratides I-IV, New Cytotoxic Cyclodepsipeptides from the Malaysian Basidiomycete Pterula sp.

详细信息    查看全文

• 作者：Chien-Hui Chen ; Gerhard Lang ; Maya I. Mitova ; Annabel C. Murphy ; Anthony L. J. Cole ; Laily B. Din ; John W. Blunt ; Murray H. G. Munro
• 刊名：Journal of Organic Chemistry
• 出版年：2006
• 出版时间：October 13, 2006
• 年：2006
• 卷：71
• 期：21
• 页码：7947 - 7951
• 全文大小：139K
• 年卷期：v.71,no.21(October 13, 2006)
• ISSN：1520-6904

文摘

D=jo060843un00002>

ALIGN="left" HSPACE=5>

Four new cyclodepsipeptides, pteratides I-IV (1-4), have been isolated from the extract of a Pterulaspecies collected from a Malaysian tropical forest. Homonuclear and heteronuclear 2D NMR techniquesas well as MS fragmentation experiments, in combination with methanolysis, determined the grossstructures of the peptides and showed that pteratides I and II each contained the nonproteinogenic aminoacid 4-methylproline. The absolute configurations of the amino acids in pteratides I-IV were establishedusing Marfey's method. Pteratides I and II are each potently cytotoxic against the P388 murine leukemiacell line (IC₅₀ values of 41 and 40 nM, respectively). Pteratides III and IV show weaker, but still notable,activity with IC₅₀ values of 7.4 and 2.9 M, respectively.