Gold Nanoparticle-Induced Formation of Artificial Protein Capsids
详细信息 查看全文
- 作者：Ali D. Malay ; Jonathan G. Heddle ; Satoshi Tomita ; Kenji Iwasaki ; Naoyuki Miyazaki ; Koji Sumitomo ; Hisao Yanagi ; Ichiro Yamashita ; Yukiharu Uraoka
- 刊名：Nano Letters
- 出版年：2012
- 出版时间：April 11, 2012
- 年：2012
- 卷：12
- 期：4
- 页码：2056-2059
- 全文大小：359K
- 年卷期：v.12,no.4(April 11, 2012)
- ISSN：1530-6992
文摘
Gold nanoparticles are generally considered to be biologically inactive. However, in this study we show that the addition of 1.4 nm diameter gold nanoparticle induces the remodeling of the ring-shaped protein TRAP into a hollow, capsid-like configuration. This structural remodeling is dependent upon the presence of cysteine residues on the TRAP surface as well as the specific type of gold nanoparticle. The results reveal an apparent novel catalytic role of gold nanoparticles.