The Synthesis of Bromomethyltrifluoroborates through Continuous Flow Chemistry
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- 作者：Toby Broom ; Mark Hughes ; Bruce G. Szczepankiewicz ; Karl Ace ; Ben Hagger ; Gary Lacking ; Ranjit Chima ; Graeme Marchbank ; Gareth Alford ; Paul Evans ; Christopher Cunningham ; John C. Roberts ; Robert B. Perni ; Malcolm Berry ; Andrew Rutter ; Simon A. Watson
- 刊名：Organic Process Research & Development
- 出版年：2014
- 出版时间：November 21, 2014
- 年：2014
- 卷：18
- 期：11
- 页码：1354-1359
- 全文大小：282K
- ISSN：1520-586X
文摘
A continuous flow process was developed for the synthesis of potassium bromomethyltrifluoroborate, a key precursor for Suzuki鈥揗iyaura coupling reagents. The continuous flow process was used to produce potassium bromomethyltrifluoroborate on scales from grams to kilograms, and the successful process utilized a fraction of the resources required for the batch synthesis. In the plant, a team of three people produced approximately 100 kg of potassium bromomethyltrifluoroborate in less than 4 weeks. This process makes it both practical and economical to use potassium bromomethyltrifluoroborate and its derivatives for multikilogram-scale Suzuki鈥揗iyaura couplings.