Synthesis of a Library of 2-Alkyl-3-alkyloxy-2H-indazole-6-carboxamides
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- 作者：Aaron D. Mills ; Patrick Maloney ; Elsayed Hassanein ; Makhluf J. Haddadin ; Mark J. Kurth
- 刊名：Journal of Combinatorial Chemistry
- 出版年：2007
- 出版时间：January 2007
- 年：2007
- 卷：9
- 期：1
- 页码：171 - 177
- 全文大小：151K
- 年卷期：v.9,no.1(January 2007)
- ISSN：1520-4774
文摘
A library of 200 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides was synthesized using parallel solution-phase methods. The indazole cyclization reaction was optimized for library production with the best yieldsresulting from controlled alcohol/water solvent ratios. The key step, a heterocyclization reaction, proceedsby N,N-bond formation and delivers the 2H-indazole scaffold. Automated preparative HPLC was utilizedto provide pure compounds on a 10+ mg scale.