Synthesis of Monoglucosylated High-Mannose-Type Dodecasaccharide, a Putative Ligand for Molecular Chaperone, Calnexin, and Calreticurin
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- 作者：Ichiro Matsuo ; Megumi Wada ; Shino Manabe ; Yoshiki Yamaguchi ; Keisuke Otake ; Koichi Kato ; and Yukishige Ito
- 刊名：Journal of the American Chemical Society
- 出版年：2003
- 出版时间：March 26, 2003
- 年：2003
- 卷：125
- 期：12
- 页码：3402 - 3403
- 全文大小：92K
- 年卷期：v.125,no.12(March 26, 2003)
- ISSN：1520-5126
文摘
Convergent and stereoselective synthetic routes to Man9GlcNAc2 (1b), 
-Glc1M9GlcNAc2 (2b), and its stereoisomer 
-Glc1M9GlcNAc2 (3) were established. Interaction analysis of 2b with CRT was measured by 1H NMR spectroscopy, and the first NMR-based evidence for the specific binding of CRT to 2b was obtained.
-Glc1M9GlcNAc2 (2b), and its stereoisomer -Glc1M9GlcNAc2 (3) were established. Interaction analysis of 2b with CRT was measured by 1H NMR spectroscopy, and the first NMR-based evidence for the specific binding of CRT to 2b was obtained.