Atypi
cal antipsy
choti
c drugs, su
ch as olanzapine, have been shown to alleviate the positive, negative an
d, to a lesser
degree, the
cognitive symptoms of s
chizophrenia in many patients. However, the
detaile
d me
chanisms of a
ction of these
drugs have yet to be elu
ci
date
d. We have
carrie
d out the first investigation aime
d at evaluating the effe
cts of olanzapine treatment on the gly
cosylation of serum proteins in s
chizophrenia patients. Olanzapine treatment resulte
d in in
crease
d levels of a
disialylate
d biantennary gly
can an
d re
du
ce
d levels of a number of
disialylate
d bi- an
d triantennary gly
cans on whole serum gly
coproteins. These
changes were not observe
d on a low-abun
dan
ce serum protein fra
ction. 伪1 a
ci
d gly
coprotein was i
dentifie
d as a
carrier of some of the
dete
cte
d altere
d oligosa
cchari
des. In a
ddition, gly
can analysis of haptoglobin, transferrin, an
d 伪1 antitrypsin reporte
d similar fin
dings, although these
changes
di
d not rea
ch signifi
can
ce. Exogly
cosi
dase
digestion analysis showe
d that olanzapine treatment in
crease
d gala
ctosylation an
d sialylation of whole serum proteins, suggesting in
crease
d a
ctivity of spe
cifi
c gala
ctosyltransferases an
d in
crease
d availability of gala
ctose resi
dues for sialylation. Taken together, these fin
dings in
di
cate that olanzapine treatment results in altere
d gly
cosylation of serum proteins.
Keywords:
d="authors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=glycosylation&qsSearchArea=searchText">glycosylation; d="authors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=schizophrenia&qsSearchArea=searchText">schizophrenia; d="authors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=olanzapine&qsSearchArea=searchText">olanzapine; d="authors" href="http://pubs.acs.org/action/doSearch?action=search&searchText=%CE%B11+acid+glycoprotein&qsSearchArea=searchText">伪1 acid glycoprotein