Glycine-Linked Nucleoside-尾-Amino Acids: Polyamide Analogues of Nucleic Acids

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• 作者：Anjan Banerjee ; Seema Bagmare ; Manojkumar Varada ; Vaijayanti A. Kumar
• 刊名：Bioconjugate Chemistry
• 出版年：2015
• 出版时间：August 19, 2015
• 年：2015
• 卷：26
• 期：8
• 页码：1737-1742
• 全文大小：274K
• ISSN：1520-4812

文摘

3鈥?5鈥?Deoxyribose-sugar-phoshate backbone in DNA is completely replaced by 2鈥?deoxyribonucleoside-based 尾-amino acids interlinked by glycine to create uncharged polyamide DNA with 3鈥?5鈥?directionality. These oligomers as conjugates of 伪-amino acids and nucleoside-尾-amino acids bind strongly and sequence-specifically only to the antiparallel complementary RNA and DNA.