Heteroaryl Ethers by Oxidative Palladium Catalysis of Pyridotriazol-1-yloxy Pyrimidines with Arylboronic Acids

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• 作者：Sujata Bardhan ; Sumrit Wacharasindhu ; Zhao-Kui Wan ; Tarek S. Mansour
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：June 18, 2009
• 年：2009
• 卷：11
• 期：12
• 页码：2511-2514
• 全文大小：217K
• 年卷期：v.11,no.12(June 18, 2009)
• ISSN：1523-7052

文摘

The oxidative palladium-catalyzed cross-coupling of pyrimidines containing pyridotriazol-1-yloxy (OPt) as either a urea or an amide functional group with arylboronic acids in the presence of Cs₂CO₃ in DME containing 0.6−1.0% H₂O is described for the preparation of heteroaryl ethers. The bromo substitution in the case of 3-(5-bromo-pyrimidin-2-yloxy)-3H-[1,2,3]triazolo[4,5-b]pyridine 1 could serve as a handle for further elaborations such as Suzuki coupling for attaching varied aryl groups.