Machilusides A and B: Structurally Unprecedented Homocucurbitane Glycosides from the Stem Bark of Machilus yaoshansis

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• 作者：Mingtao Liu ; Maoluo Gan ; Sheng Lin ; Yanling Zhang ; Jiachen Zi ; Weixia Song ; Xiaona Fan ; Ying Liu ; Yongchun Yang ; Jiangong Shi
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：June 3, 2011
• 年：2011
• 卷：13
• 期：11
• 页码：2856-2859
• 全文大小：737K
• 年卷期：v.13,no.11(June 3, 2011)
• ISSN：1523-7052

文摘

Two structurally novel homocucurbitane triterpenoid glycosides, machilusides A (1) and B (2), possessing an unprecedented C₃₆ skeleton with a d-fructose moiety incorporated into a cucurbitane nucleus forming unique cage-like tricyclic ring moieties, were isolated from the stem bark of Machilus yaoshansis. Their structures were determined by spectroscopic methods. Both compounds exhibited nonselective cytotoxic activities against several human cancer cell lines. The biosynthetic pathway of 1 and 2 was postulated.