PdCl2-Catalyzed Oxidative Cycloisomerization of 3-Cyclopropylideneprop-2-en-1-ones

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• 作者：Maozhong Miao ; Jian Cao ; Jingjing Zhang ; Xian Huang ; Luling Wu
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：June 1, 2012
• 年：2012
• 卷：14
• 期：11
• 页码：2718-2721
• 全文大小：246K
• 年卷期：v.14,no.11(June 1, 2012)
• ISSN：1523-7052

文摘

A novel PdCl₂-catalyzed oxidative cycloisomerization of 3-cyclopropylideneprop-2-en-1-ones, providing a facile synthesis of highly strained functionalized 2-alkylidenecyclobutanones via furan-fused cyclobutene intermediates, is reported. An interesting route to 2(3H)-furanones with a spiro-cyclopropane unit from the obtained 2-alkylidenecyclobutanones via a ring-contraction rearrangement reaction is also realized.