Enantioselective Intramolecular C鈥揌 Insertion Reactions of Donor鈥揇onor Metal Carbenoids
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- 作者：Cristian Soldi ; Kellan N. Lamb ; Richard A. Squitieri ; Marcos Gonz谩lez-L贸pez ; Michael J. Di Maso ; Jared T. Shaw
- 刊名：Journal of the American Chemical Society
- 出版年：2014
- 出版时间：October 29, 2014
- 年：2014
- 卷：136
- 期：43
- 页码：15142-15145
- 全文大小：383K
- ISSN：1520-5126
文摘
The first asymmetric insertion reactions of donor鈥揹onor carbenoids, i.e., those with no pendant electron-withdrawing groups, are reported. This process enables the synthesis of densely substituted benzodihydrofurans with high levels of enantio- and diastereoselectivity. Preliminary results show similar efficiency in the preparation of indanes. This new method is used in the first enantioselective synthesis of an oligoresveratrol natural product (E-未-viniferin).