Metal-Mediated Tandem Coassembly of Collagen Peptides into Banded Microstructures

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• 作者：Marcos M. Pires ; David E. Przybyla ; Charles M. Rubert P茅rez ; Jean Chmielewski
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：September 21, 2011
• 年：2011
• 卷：133
• 期：37
• 页码：14469-14471
• 全文大小：727K
• 年卷期：v.133,no.37(September 21, 2011)
• ISSN：1520-5126

文摘

The ability to recapitulate the features of natural collagen at the micro- and nanoscale with novel biopolymers has the potential to lead to improved biomaterials. Herein we describe stimuli-responsive collagen-based peptides (IdaCol and HisCol) that together form higher order assemblies in the presence of added metal ions. SEM and TEM imaging of these assemblies revealed microscale petal-like and intertwined fiber morphologies, each with periodic banding on the nanometer scale. The observed banding is consistent with tandem coassembly of alternating IdaCol and HisCol triple helical blocks that may laterally associate either in or out of register to form higher order structures, and mimics the banding found in natural collagen fibers.