[1-8-NαC]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum
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- 作者：Pâmela J. dos S. Beirigo ; Heron F. V. Torquato ; Carlos H. C. dos Santos ; Mário G. de Carvalho ; Rosane N. Castro ; Edgar J. Paredes-Gamero ; Paulo T. de Sousa Jr. ; Marcos J. Jacinto ; Virgínia C. da Silva
- 刊名：Journal of Natural Products
- 出版年：2016
- 出版时间：May 27, 2016
- 年：2016
- 卷：79
- 期：5
- 页码：1454-1458
- 全文大小：274K
- 年卷期：0
- ISSN：1520-6025
文摘
A new orbitide named [1-8-NαC]-zanriorb A1 (1) was isolated and characterized from the leaves of Zanthoxylum riedelianum using NMR and mass spectrometry. The absolute configuration of the amino acids was determined using Marfey’s method on the acid hydrolysates. Compound 1 induced cell death by apoptosis in Jurkat leukemia T cells (IC50 218 nM).