Protein-Resistant Silicones: Incorporation of Poly(ethylene oxide) via Siloxane Tethers

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• 作者：Ranjini Murthy ; Casey D. Cox ; Mariah S. Hahn ; Melissa A. Grunlan
• 刊名：Biomacromolecules
• 出版年：2007
• 出版时间：October 2007
• 年：2007
• 卷：8
• 期：10
• 页码：3244 - 3252
• 全文大小：376K
• 年卷期：v.8,no.10(October 2007)
• ISSN：1526-4602

文摘

Silicones with enhanced protein resistance were prepared by introducing poly(ethylene oxide) (PEO) chains viasiloxane tethers (a-c) of varying lengths. Three unique ambifunctional molecules (a-c) having the general formula-(EtO)₃Si(CH₂)₂-oligodimethylsiloxane_n-block-poly(ethylene oxide)₈-OCH₃ (n = 0 (a), 4, (b), and 13 (c)) wereprepared via regioselective Rh-catalyzed hydrosilylation. Nine films were subsequently produced by the H₃PO₄-catalyzed sol-gel cross-linking of a-c each with ,-bis(Si-OH)polydimethylsiloxane (P, M_n = 3000 g/mol)in varying ratios (1:1, 1:2, and 2:3 molar ratio a, b, or c to P). Films prepared with a 2:3 molar ratio (a-c to P)contained the least amount of un-cross-linked materials, which may migrate to the film surface. For this set offilms, surface hydrophilicity and protein resistance increased with siloxane tether length (a-c). These resultsindicate that PEO was more effectively mobilized to the surface if incorporated into silicones via longer siloxanetethers.