Quercetin's Solubility Affects Its Accumulation in Rat Plasma after Oral Administration
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- 作者：Mariusz K. Piskula and Junji Terao
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：1998
- 出版时间：October 1998
- 年：1998
- 卷：46
- 期：10
- 页码：4313 - 4317
- 全文大小：66K
- 年卷期：v.46,no.10(October 1998)
- ISSN：1520-5118
文摘
Absorption of quercetin, a flavonoid regarded as a beneficial dietary factor, was studied in rats.The compound was administered orally in propylene glycol, water/propylene glycol, and water.Quercetin's solubility in vehicles used for quercetin administration was measured. Followingadministration, tail vein blood was collected as a function of time. Concentrations of quercetin andits metabolites in rat blood plasma were measured by HPLC with electrochemical detection afterhydrolysis of respective conjugates with 
-glucuronidase and/or sulfatase. Pharmacokinetic profilesof quercetin and isorhamnetin, its 3'-methoxy derivative, were obtained, and on their basis it wasconcluded that isorhamnetin was present in rat blood plasma mainly as sulfate/glucuronideconjugates. Quercetin's solubility in solvents used for its administration was compared withrespective absorption profiles. This comparison revealed that solubilization enhanced quercetinabsorption; however, its lack was not an absorption-limiting factor.Keywords: Flavonoid absorption; quercetin; isorhamnetin; glucuronide; rat
-glucuronidase and/or sulfatase. Pharmacokinetic profilesof quercetin and isorhamnetin, its 3'-methoxy derivative, were obtained, and on their basis it wasconcluded that isorhamnetin was present in rat blood plasma mainly as sulfate/glucuronideconjugates. Quercetin's solubility in solvents used for its administration was compared withrespective absorption profiles. This comparison revealed that solubilization enhanced quercetinabsorption; however, its lack was not an absorption-limiting factor.Keywords: Flavonoid absorption; quercetin; isorhamnetin; glucuronide; rat