Bioavailability of Cyanidin Glycosides from Natural Chokeberry (Aronia melanocarpa) Juice with Dietary-Relevant Dose of Anthocyanins in Humans
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- 作者：Wieslaw Wiczkowski ; Ewa Romaszko ; Mariusz K. Piskula
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2010
- 出版时间：December 8, 2010
- 年：2010
- 卷：58
- 期：23
- 页码：12130-12136
- 全文大小：778K
- 年卷期：v.58,no.23(December 8, 2010)
- ISSN：1520-5118
文摘
The aim of this study was to investigate the bioavailability of anthocyanins from chokeberry juice with a dietary-relevant dose of anthocyanins. Thirteen healthy volunteers consumed chokeberry juice providing 0.8 mg of anthocyanins/kg of body weight. Before and after juice consumption, blood and urine were collected. Concentration of anthocyanins was measured with HPLC-PDA−MS-ESI. Cyanidin-3-galactoside comprised 66% of total chokeberry anthocyanins. Eight cyanidin derivatives were found in blood and urine after juice consumption. The maximum plasma anthocyanin concentration of 32.7 ± 2.9 nmol/L was reached at 1.3 ± 0.1 h after juice consumption. The anthocyanins’ urine excretion rate (62.9 ± 5.0 nmol/h) was the highest within the first 2 h. In total, 0.25 ± 0.02% of the ingested anthocyanins was excreted by the renal route during 24 h, mainly as metabolites of cyanidin. According to these observations, after consumption of a dietary-relevant dose of anthocyanins as natural chokeberry juice, anthocyanins and their metabolites were present in plasma and urine of volunteers.