Hindered Disulfide Bonds to Regulate Release Rate of Model Drug from Mesoporous Silica
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- 作者：Peter Nadrah ; Uro拧 Maver ; Anita Jemec ; Tatjana Ti拧ler ; Marjan Bele ; Goran Dra啪i膰 ; Mojca Ben膷ina ; Albin Pintar ; Odon Planin拧ek ; Miran Gaber拧膷ek
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2013
- 出版时间：May 8, 2013
- 年：2013
- 卷：5
- 期：9
- 页码：3908-3915
- 全文大小：402K
- 年卷期：v.5,no.9(May 8, 2013)
- ISSN：1944-8252
文摘
With the advancement of drug delivery systems based on mesoporous silica nanoparticles (MSNs), a simple and efficient method regulating the drug release kinetics is needed. We developed redox-responsive release systems with three levels of hindrance around the disulfide bond. A model drug (rhodamine B dye) was loaded into MSNs鈥?mesoporous voids. The pore opening was capped with 尾-cyclodextrin in order to prevent leakage of drug. Indeed, in absence of a reducing agent the systems exhibited little leakage, while the addition of dithiothreitol cleaved the disulfide bonds and enabled the release of cargo. The release rate and the amount of released dye were tuned by the level of hindrance around disulfide bonds, with the increased hindrance causing a decrease in the release rate as well as in the amount of released drug. Thus, we demonstrated the ability of the present mesoporous systems to intrinsically control the release rate and the amount of the released cargo by only minor structural variations. Furthermore, an in vivo experiment on zebrafish confirmed that the present model delivery system is nonteratogenic.