Photothermal Single-Particle Microscopy: Detection of a Nanolens
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- 作者：Markus Selmke ; Marco Braun ; Frank Cichos
- 刊名：ACS Nano
- 出版年：2012
- 出版时间：March 27, 2012
- 年：2012
- 卷：6
- 期：3
- 页码：2741-2749
- 全文大小：585K
- 年卷期：v.6,no.3(March 27, 2012)
- ISSN：1936-086X
文摘
Combining quantitative photothermal microscopy and light scattering microscopy as well as accurate MIE scattering calculations on single gold nanoparticles, we reveal that the mechanism of photothermal single-molecule/particle detection is quantitatively explained by a nanolensing effect. The lensing action is the result of the long-range character of the refractive index profile. It splits the focal detection volume into two regions. Our results lay the foundation for future developments and quantitative applications of single-molecule absorption microscopy.