Pharmacokinetic Comparison of Soy Isoflavone Extracts in Human Plasma

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• 作者：Jose Rodr铆guez-Morat贸 ; Mag铆 Farr茅 ; Clara P茅rez-Ma帽谩 ; Esther Papaseit ; Roser Mart铆nez-Riera ; Rafael de la Torre ; Nieves Pizarro
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2015
• 出版时间：August 12, 2015
• 年：2015
• 卷：63
• 期：31
• 页码：6946-6953
• 全文大小：303K
• ISSN：1520-5118

文摘

The soy isoflavones daidzein and genistein produce several biological activities related to health benefits. A number of isoflavone extracts are commercially available, but there is little information concerning the specific isoflavone content of these products or differences in their bioavailability and pharmacokinetics. This study describes the development and validation of an analytical method to detect and quantify daidzein, genistein, and equol in human plasma using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The method was applied in a crossover, randomized, bioavailability study. Twelve healthy volunteers were administered the same total isoflavones dose from two isoflavone supplement preparations (Super-Absorbable Soy Isoflavones (Life Extension, USA) and Fitoladius (Merck, Spain)). The pharmacokinetic parameters (AUC<sub>0鈥?4sub>/dose and C<sub>maxsub>/dose) of the isoflavones from the two preparations differed significantly. Such differences in bioavailability and kinetics may have relevant effects on the health benefits derived from their intake.