MoSe2 Nanolabels for Electrochemical Immunoassays

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• 作者：Rou Jun Toh ; Carmen C. Mayorga-Martinez ; Zdeněk Sofer ; Martin Pumera
• 刊名：Analytical Chemistry
• 出版年：2016
• 出版时间：December 20, 2016
• 年：2016
• 卷：88
• 期：24
• 页码：12204-12209
• 全文大小：356K
• ISSN：1520-6882

文摘

There is huge interest in biosensors as a result of the demand for personalized medicine. In biomolecular detection, transition-metal dichalcogenides (TMDs) can be used as signal-enhancing elements. Herein, we utilize a solution-based electrochemical exfoliation technique with bipolar electrodes to manufacture MoSe₂ nanolabels for biomolecular detection. Prepared MoSe₂ nanoparticles (NPs) exhibit electrocatalytic activity toward the hydrogen evolution reaction (HER), and such a property allows it to act as a robust label for magneto-immunoassays toward protein detection. The magneto-immunoassay also displayed good selectivity, a wide linear range of 2 to 500 ng mL^–1, high sensitivity (LOD = 1.23 ng mL^–1) and reproducibility (RSD = 9.7%). These findings establish the viability and reproducibility of such an exfoliation technique for TMD nanolabels for the development of low costs and efficient biosensing systems.