The B(C6F5)3-Catalyzed Tandem Meinwald Rearrangement–Reductive Amination

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• 作者：Martine R. Tiddens ; Robertus J. M. Klein Gebbink ; Matthias Otte
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：18
• 期：15
• 页码：3714-3717
• 全文大小：294K
• 年卷期：0
• ISSN：1523-7052

文摘

A system of three coupled catalytic cycles enabling the one-pot transformation of epoxides to amines via Meinwald rearrangement, imine condensation, and imine reduction is described. This assisted tandem catalysis is catalyzed by B(C₆F₅)₃ resulting in the first tandem Meinwald rearrangement–reductive amination protocol. The reaction proceeds in nondried solvents and yields β-functionalized amines. In particular, β-diarylamines are obtained in high yields.