Plumisclerin A, a Diterpene with a New Skeleton from the Soft Coral Plumigorgia terminosclera

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• 作者：Mara Jess Martn ; Rogelio Fernndez ; Andrs Francesch ; Philippe Amade ; Susana S. de Matos-Pita ; Fernando Reyes ; Carmen Cuevas
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：March 5, 2010
• 年：2010
• 卷：12
• 期：5
• 页码：912-914
• 全文大小：152K
• 年卷期：v.12,no.5(March 5, 2010)
• ISSN：1523-7052

文摘

A novel compound, named plumisclerin A (1), was isolated from samples of the soft coral Plumigorgia terminosclera collected at Mayotte Island. The compound possesses the novel plumisclerane carbon skeleton, including a tricyclo[4,3,1,0^1,5]decane ring. Its structure and relative stereochemistry were elucidated by extensive spectroscopic analysis, including HREIMS, COSY, HSQC, HMBC, TOCSY, and NOESY experiments. In addition, the novel compound displayed in vitro cytotoxicity against selected cancer cell lines.