Fabrication and Characterization of a Nanometer-Sized Optical Fiber Electrode Based on Selective Chemical Etching for Scanning Electrochemical/Optical Microscopy
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- 作者：Kenichi Maruyama ; Hiroyuki Ohkawa ; Sho Ogawa ; Akio Ueda ; Osamu Niwa ; and Koji Suzuki
- 刊名：Analytical Chemistry
- 出版年：2006
- 出版时间：March 15, 2006
- 年：2006
- 卷：78
- 期：6
- 页码：1904 - 1912
- 全文大小：475K
- 年卷期：v.78,no.6(March 15, 2006)
- ISSN：1520-6882
文摘
We have already reported a method for fabricating ultramicroelectrodes (Suzuki, K. JP Patent, 2004-45394,2004). This method is based on the selective chemicaletching of optical fibers. In this work, we undertake adetailed investigation involving a combination of etchedoptical fibers with various types of tapered tip (protruding-shape, double- (or pencil-) shape and triple-taperedelectrode) and insulation with electrophoretic paint. Ourgoal is to establish a method for fabricating nanometer-sized optical fiber electrodes with high reproducibility. Asa result, we realized pencil-shaped and triple-taperedelectrodes that had radii in the nanometer range with highreproducibility. These nanometer-sized electrodes showedwell-defined sigmoidal curves and stable diffusion-limitedresponses with cyclic voltammetry. The pencil-shapedoptical fiber, which has a conical tip with a cone angle of20
, was effective for controlling the electrode radius. Thepencil-shaped electrodes had higher reproducibility andsmaller electrode radii (rapp < 1.0 nm) than those of otheretched optical fiber electrodes. By using a pencil-shapedelectrode with a 105-nm radius as a probe, we obtainedsimultaneous electrochemical and optical images of animplantable interdigitated array electrode. We achievednanometer-scale resolution with a combination of scanning electrochemical microscopy SECM and optical microscopy. The resolution of the electrochemical andoptical images indicated sizes of 300 and 930 nm,respectively. The neurites of living PC12 cells were alsosuccessfully imaged on a 1.6-
m scale by using thenegative feedback mode of an SECM.
, was effective for controlling the electrode radius. Thepencil-shaped electrodes had higher reproducibility andsmaller electrode radii (rapp < 1.0 nm) than those of otheretched optical fiber electrodes. By using a pencil-shapedelectrode with a 105-nm radius as a probe, we obtainedsimultaneous electrochemical and optical images of animplantable interdigitated array electrode. We achievednanometer-scale resolution with a combination of scanning electrochemical microscopy SECM and optical microscopy. The resolution of the electrochemical andoptical images indicated sizes of 300 and 930 nm,respectively. The neurites of living PC12 cells were alsosuccessfully imaged on a 1.6-m scale by using thenegative feedback mode of an SECM.