Isolation of Steroidal Glycosides from the Caribbean Sponge Pandaros acanthifolium

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• 作者：Fabrice Berru茅 ; Malcolm W. B. McCulloch ; Patricia Boland ; Saskia Hart ; Mary Kay Harper ; James Johnston ; Russell Kerr
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：December 28, 2012
• 年：2012
• 卷：75
• 期：12
• 页码：2094-2100
• 全文大小：261K
• 年卷期：v.75,no.12(December 28, 2012)
• ISSN：1520-6025

文摘

Four new steroidal glycosides, acanthifoliosides G鈥揓 (1鈥?b>4), were isolated as minor constituents from the Caribbean marine sponge Pandaros acanthifolium. These metabolites are characterized by a highly oxygenated D ring and the presence of a disaccharide rhamnose-glucose residue and a rhamnose at positions C-3 and C-15, respectively. Their structures were established on the basis of extensive interpretation of 1D and 2D NMR data and HRESIMS analyses. The absolute configurations of the glucose and rhamnose sugars were determined by preparing aldose o-tolylthiocarbamate derivatives and comparison to authentic standards by LC/HRESIMS. Acanthifolioside G (1) exhibited antioxidant and cytoprotective activities.