Molecules That Mimic Apolipoprotein A-I: Potential Agents for Treating Atherosclerosis

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• 作者：Luke J. Leman ; Bruce E. Maryanoff ; M. Reza Ghadiri
• 刊名：Journal of Medicinal Chemistry
• 出版年：2014
• 出版时间：March 27, 2014
• 年：2014
• 卷：57
• 期：6
• 页码：2169-2196
• 全文大小：794K
• 年卷期：v.57,no.6(March 27, 2014)
• ISSN：1520-4804

文摘

Certain amphipathic 伪-helical peptides can functionally mimic many of the properties of full-length apolipoproteins, thereby offering an approach to modulate high-density lipoprotein (HDL) for combating atherosclerosis. In this Perspective, we summarize the key findings and advances over the past 25 years in the development of peptides that mimic apolipoproteins, especially apolipoprotein A-I (apoA-I). This assemblage of information provides a reasonably clear picture of the state of the art in the apolipoprotein mimetic field, an appreciation of the potential for such agents in pharmacotherapy, and a sense of the opportunities for optimizing the functional properties of HDL.