One-Pot Synthesis of Optically Active Allyl Esters via Lipase−Vanadium Combo Catalysis

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• 作者：Shuji Akai ; Ryosuke Hanada ; Noboru Fujiwara ; Yasuyuki Kita ; Masahiro Egi
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：November 5, 2010
• 年：2010
• 卷：12
• 期：21
• 页码：4900-4903
• 全文大小：267K
• 年卷期：v.12,no.21(November 5, 2010)
• ISSN：1523-7052

文摘

The combination of vanadium-oxo compounds (3 or 4) with a lipase produced the regio- and enantioconvergent transformation of racemic allyl alcohols (1 or 2) into optically active allyl esters. In this system, the vanadium compounds catalyzed the continuous racemization of the alcohols along with the transposition of the hydroxyl group, while the lipase effected the chemo- and enantioselective esterification to achieve the dynamic kinetic resolution.