Ruthenium-Catalyzed Regioselective C–H Bond Acetoxylation on Carbazole and Indole Frameworks

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• 作者：Takeshi Okada ; Kazunori Nobushige ; Tetsuya Satoh ; Masahiro Miura
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：March 4, 2016
• 年：2016
• 卷：18
• 期：5
• 页码：1150-1153
• 全文大小：414K
• ISSN：1523-7052

文摘

The regioselective C–H bond cleavage/C–O bond formation takes place smoothly upon treatment of 9-(pyridin-2-yl)carbazoles with acetic acid in the presence of a silver salt oxidant under ruthenium catalysis to afford the corresponding C1- and C8-diacetoxylated products. Under similar conditions, the acetoxylation of 2-aryl-1-(pyridin-2-yl)indoles as well as 1-aryl-7-azaindoles can also be conducted efficiently.