Intramolecular Hydroalkoxylation of Unactivated Alkenes Using Silane鈥揑odine Catalytic System

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• 作者：Shoji Fujita ; Masanori Abe ; Masatoshi Shibuya ; Yoshihiko Yamamoto
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：August 7, 2015
• 年：2015
• 卷：17
• 期：15
• 页码：3822-3825
• 全文大小：336K
• ISSN：1523-7052

文摘

A novel catalytic system using I₂ and PhSiH₃ for the intramolecular hydroalkoxylation of unactivated alkenes is described. NMR study indicated that in situ generated PhSiH₂I is a possible active catalytic species. This catalytic system allows an efficient intramolecular hydroalkoxylation of phenyl-, trialkyl-, and 1,1-dialkyl-substituted alkenes as well as a variety of unactivated monoalkyl- and 1,2-dialkyl-substituted alkenes at room temperature. Mechanistic consideration based on significant experimental observations is also discussed.