Composition Dependence of the Micellar Architecture Made from Poly(ethylene glycol)-block-Poly(partially benzyl-esterified aspartic acid)

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• 作者：Yusuke Sanada ; Isamu Akiba ; Satoshi Hashida ; Kazuo Sakurai ; Kouichi Shiraishi ; Masayuki Yokoyama ; Naoto Yagi ; Yuya Shinohara ; Yoshiyuki Amemiya
• 刊名：The Journal of Physical Chemistry B
• 出版年：2012
• 出版时间：July 19, 2012
• 年：2012
• 卷：116
• 期：28
• 页码：8241-8250
• 全文大小：427K
• 年卷期：v.116,no.28(July 19, 2012)
• ISSN：1520-5207

文摘

Poly(ethylene glycol)-block-poly(partially benzyl-esterified aspartic acid), denoted by PEG-P(Asp(Bzl)), is one of the most examined blockcopolymers for drug carriers. However, little is known about fundamental physical properties. Nine samples of PEG-P(Asp(Bzl)) with different benzylation fractions (F_Bzl) and aspartic chain lengths (DP_Asp) were synthesized, and the aggregation number (N_agg), core radius (R_C), and other structural parameters were determined with combination of light scattering and synchrotron X-ray small-angle scattering. The major factor to determine N_agg and R_C was found to be F_Bzl, i.e., the hydrophobic nature of the core, even though F_Bzl was changed in the relatively small composition range from 66 to 89 mol %. When we compared the data for the same F_Bzl, the scaling theory was consistent with the core chain length dependence of both core and micelle sizes. The overcrowding nature of the tethered PEG chains on the micelles was increased about 1.3鈥?.9 times with increasing N_agg compared with the unperturbed state in solutions.