Modeling the Phase Behavior of the Membrane Binding Protein Annexin V

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• 作者：Massimo G. Noro ; Martin A. Bates ; Alain Brisson ; and Daan Frenkel
• 刊名：Langmuir
• 出版年：2002
• 出版时间：April 16, 2002
• 年：2002
• 卷：18
• 期：8
• 页码：2988 - 2992
• 全文大小：705K
• 年卷期：v.18,no.8(April 16, 2002)
• ISSN：1520-5827

文摘

The bulk thermodynamic properties of proteins originate from a varied and complex combination ofinteractions. We propose a simple model for the formation of ordered two-dimensional aggregates basedon the interactions between pairs of annexin V molecules. Simulations of this model are shown to reproducethe experimental observations of a honeycomb (p6) and a triangular (p3) crystalline phase. The simulationsindicate that the transition between these two phases is first order. While this model is extremely simplein that it relies only on hard body and short-range directional interactions, it nevertheless captures theessential physics of the interactions between the protein molecules and reproduces the phase behaviorobserved in electron microscopy and atomic force microscopy experiments.