Antifungal and Cytotoxic 2-Acylcyclohexane-1,3-diones from Peperomia alata and P. trineura

详细信息    查看全文

• 作者：Edgard A. Ferreira ; Juliana B. Reigada ; Mauro V. Correia ; Maria C. M. Young ; Elsie F. Guimar茫es ; Gilberto C. Franchi ; Jr. ; Alexandre E. Nowill ; Jo茫o H. G. Lago ; Lydia F. Yamaguchi ; Massuo J. Kato
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：June 27, 2014
• 年：2014
• 卷：77
• 期：6
• 页码：1377-1382
• 全文大小：241K
• ISSN：1520-6025

文摘

Bioactivity-guided fractionation of the separate CH₂Cl₂ extracts from the aerial parts of Peperomia alata and P. trineura yielded seven polyketides: alatanone A [3-hydroxy-2-(5鈥?phenylpent-4鈥?i>E-enoyl)cyclohex-2-en-1-one, 1a] and alatanone B [3-hydroxy-2-(3鈥?phenyl-6鈥?methylenedioxypropanoyl)cyclohex-2-en-1-one, 2a] from P. alata and trineurone A [3-hydroxy-2-(11鈥?phenylundec-10鈥?i>E-enoyl)cyclohex-2-en-1-one, 1b], trineurone B [3-hydroxy-2-(15鈥?phenyl-18鈥?methylenedioxypentadecanoyl)cyclohex-2-en-1-one, 2b], trineurone C [3-hydroxy-2-(17鈥?phenyl-20鈥?methylenedioxyheptadecanoyl)cyclohex-2-en-1-one, 2c], trineurone D [3-hydroxy-2-(hexadec-10鈥?i>Z-enoyl)cyclohex-2-en-1-one, 3a], and trineurone E [(6R)-(+)-3,6-dihydroxy-2-(hexadec-10鈥?i>Z-enoyl)cyclohex-2-en-1-one, 3b] from P. trineura. The isolated compounds were evaluated for antifungal activity against Cladosporium cladosporioides and C. sphaeospermum and for cytotoxicity against the K562 and Nalm-6 leukemia cell lines.