Catalytic Direct Cross-Coupling of Organolithium Compounds with Aryl Chlorides

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• 作者：Valent铆n Hornillos ; Massimo Giannerini ; Carlos Vila ; Mart铆n Fa帽an谩s-Mastral ; Ben L. Feringa
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：October 4, 2013
• 年：2013
• 卷：15
• 期：19
• 页码：5114-5117
• 全文大小：255K
• 年卷期：v.15,no.19(October 4, 2013)
• ISSN：1523-7052

文摘

Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithium compounds is reported. The use of Pd-PEPPSI-IPent or Pd₂(dba)₃/XPhos as the catalyst allows for the preparation of biaryl and heterobiaryl compounds in high yields under mild conditions (room temperature to 40 掳C) with short reaction times.