Catalytic Enantioselective Strecker Reaction of Ketoimines
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- 作者：Shuji Masumoto ; Hiroyuki Usuda ; Masato Suzuki ; Motomu Kanai ; and Masakatsu Shibasaki
- 刊名：Journal of the American Chemical Society
- 出版年：2003
- 出版时间：May 14, 2003
- 年：2003
- 卷：125
- 期：19
- 页码：5634 - 5635
- 全文大小：64K
- 年卷期：v.125,no.19(May 14, 2003)
- ISSN：1520-5126
文摘
A new method for the catalytic enantioselective Strecker reaction (cyanation) of N-diphenylphosphinoyl ketoimines is described. The asymmetric catalyst is a chiral gadolinium complex prepared from Gd(OiPr)3 and the D-glucose-derived ligand 3 in a 1:2 ratio. The reaction has a broad substrate generality, giving high enantioselectivity from aromatic, ethyl, primary alkyl, and 
,
-unsaturated ketoimines. The products could be easily converted to disubstituted -amino acids and their derivatives.
,-unsaturated ketoimines. The products could be easily converted to disubstituted -amino acids and their derivatives.