Formation of a Hydrogen-Bonded Barbiturate [2]-Rotaxane

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• 作者：Arnaud Tron ; Peter J. Thornton ; Mathias Rocher ; Henri-Pierre Jacquot de Rouville ; Jean-Pierre Desvergne ; Brice Kauffmann ; Thierry Buffeteau ; Dominique Cavagnat ; James H. R. Tucker ; Nathan D. McClenaghan
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：March 7, 2014
• 年：2014
• 卷：16
• 期：5
• 页码：1358-1361
• 全文大小：259K
• 年卷期：v.16,no.5(March 7, 2014)
• ISSN：1523-7052

文摘

Interlocked structures containing the classic Hamilton barbiturate binding motif comprising two 2,6-diamidopyridine units are reported for the first time. Stable [2]-rotaxanes can be accessed either through hydrogen-bonded preorganization by a barbiturate thread followed by a Cu⁺-catalyzed 鈥渃lick鈥?stoppering reaction or by a Cu²⁺-mediated Glaser homocoupling reaction.