Preparation of 14C-Labeled Multiwalled Carbon Nanotubes for Biodistribution Investigations

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• 作者：Dominique Georgin ; Bertrand Czarny ; Magali Botquin ; Martine Mayne-L’ ; Hermite ; Mathieu Pinault ; Brigitte Bouchet-Fabre ; Marie Carriere ; Jean-Luc Poncy ; Quang Chau ; Rmy Maximilien ; Vincent Dive ; Frd
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：October 21, 2009
• 年：2009
• 卷：131
• 期：41
• 页码：14658-14659
• 全文大小：168K
• 年卷期：v.131,no.41(October 21, 2009)
• ISSN：1520-5126

文摘

A new method allowing the ¹⁴C-labeling of carboxylic acid functions of carbon nanotubes is described. The key step of the labeling process is a decarbonylation reaction that has been developed and optimized with the help of a screening method. The optimized process has been successfully applied to multiwalled carbon nanotubes (MWNTs), and the corresponding ¹⁴C-labeled nanotubes were used to investigate their in vivo behavior. Preliminary results obtained after i.v. contamination of rats revealed liver as the main target organ. Radiolabeling of NTs with a long-life radioactive nucleus like ¹⁴C, coupled to a highly sensitive autoradiographic method, that provides a unique detection threshold, will make it possible to determine for a long time period whether or not NTs remain in any organs after animal exposure.